Parkinsoni tõbi on krooniline neurodegeneratiivne haigus, mis mõjutab motoorikat, meeleolu ja kognitiivseid funktsioone. Kuigi täielikku ravi pole veel leitud, on üha enam tähelepanu pälvinud kanepiravi võimalused, eriti sümptomite leevendamisel.

1. Mida näitavad tänased teadusuuringud?

• Süsteemne ülevaade, mis hõlmas 5 kontrollitud ja 18 vaatlevat uuringut, leidis, et kanepi kasutamist Parkinsoni raviks ei saa veel täielikult soovitada, kuid täheldati potentsiaalseid eeliseid: vähenenud ärevus, parem uni, vähenenud valu ja paranenud üldine elukvaliteet.
  Allikas: PubMed – 2022
• Mitmed patsiendijuhud on näidanud leevendust sellistes sümptomites nagu värinad, jäikus, unetus ja ärevus. Mõned patsiendid kogesid ka paremat keskendumist ja emotsionaalset tasakaalu.
  Allikas:PCLA.org
  2025. aasta juhtumiuuringus kasutati väikestes doosides THC ja CBD ekstrakti ning märgati une kvaliteedi olulist paranemist 60 päeva jooksul. Mõnedel patsientidel täheldati ka kognitiivset paranemist.
        Allikas: Frontiers in Human Neuroscience

2. Kliinilised leiud ja uuringud

• 2023. aasta uuringus, kus osales 69 Parkinsoni patsienti, märkis 87% patsientidest sümptomite leevenemist vähemalt ühes aspektis. Lisaks suutis 56% neist vähendada või lõpetada opioidide tarbimist.
        Allikas: Psychopharmacology Institute
• Austria kliinilises uuringus testiti nabilooni – sünteetiline kannabinoid, mis mõjub sarnaselt THC-le – 47 Parkinsoni patsiendil. Tulemused näitasid paremat und ja vähem ärevust.
  Allikas: Parkinson’s UK

3. Ohutus ja piirangud

• Praegused uuringud on paljutõotavad, kuid piiratud väikeste valimite ja vähese standardiseerimise tõttu. On vaja ulatuslikke, randomiseeritud kliinilisi katseid.
  Allikad: Parkinson.org
• Võimalikud kõrvaltoimed: kognitiivne udu, peapööritus, nägemishäired. Eriti ettevaatlik tuleb olla kognitiivse langusega patsientide puhul.
• Pikaajaline kasutamine ei ole seostatud depressiooni ega kognitiivsete funktsioonide halvenemisega, kuid see nõuab veel kinnitamist.
  Allikas: ScienceDirect

4. Tulevikuvaade

• Arenduses on ka uued molekulid, mis võivad mõjutada Parkinsoni kulgu ilma THC kõrvaltoimeteta. Näiteks uuritakse praegu KLS-13019 molekuli, mille arendust toetab Michael J. Fox Foundation.
  Allikas: Wikipedia – Kannalife

Conclusion

Conclusion

Meditsiiniline kanep pakub Parkinsoni tõve sümptomite leevendamisel tõotavat suunda, eriti unehäirete, ärevuse ja valu puhul. Kuigi see ei ole imeravim, võib see olla tõhus toetav teraapia – eriti juhul, kui see toimub arstliku järelvalve ja teadusliku lähenemise raames.

ADHD (Attention Deficit Hyperactivity Disorder) is a neurodevelopmental disorder that affects a person’s ability to concentrate, control impulses, and regulate behavior. This condition often occurs in children but can persist into adulthood.

The main symptoms of ADHD are:

• Inattention – difficulty concentrating, forgetfulness, problems with organization.
• Hyperactivity – restlessness, constant need to move.
• Impulsivity – sudden reactions, impatience, impulsive behavior.

Can cannabinoids like CBD and CBG help with ADHD?

In recent years, cannabinoids—especially CBD (cannabidiol) and CBG (cannabigerol)—have gained significant attention for their potential in alleviating ADHD symptoms. Although research in this area is still limited, some individuals have found these natural substances helpful.

How do CBD and CBG affect ADHD?

CBD and CBG interact with the endocannabinoid system (ECS), which regulates mood, stress, focus, and sleep. Their potential effects on ADHD include:

1. Reducing anxiety and stress
   • CBD is known for its calming and anxiety-reducing properties, which can help with impulsivity and restlessness.
   • CBG may also assist in mood stabilization.
2. Improving focus and attention
   • Some studies and user experiences suggest that CBD may reduce "brain fog" and enhance the ability to concentrate.
   • CBG has neuroprotective effects and may support brain function.
3. Improving sleep quality
   • People with ADHD often experience sleep issues. CBD has shown potential to improve sleep quality and help with falling asleep faster.
4. Reducing impulsivity
   • Since CBD has a calming effect, it may help individuals better control their behavior and reduce sudden reactions.

CBD vs. CBG for ADHD

• CBD is better known and more widely used, particularly for its calming effects.
• CBG is less researched but may have a stronger impact on focus and cognitive support.

What does science say?

Although preliminary studies and anecdotal reports suggest potential benefits of cannabinoids, CBD and CBG have not yet been approved as official treatments for ADHD. They are also not substitutes for established ADHD medications like methylphenidate (Ritalin) or lisdexamfetamine (Elvanse).

How to use CBD or CBG for ADHD?

If you’re considering their use, it is recommended to:

• Start with a low dose and monitor your body’s response.
• Use only high-quality, lab-tested products.
• Consult a doctor, especially if you are taking ADHD medication, to avoid potential interactions.
• CBD and CBG can be consumed in various forms, such as oils, capsules, and crystals. Crystals offer faster effects, as they are quickly absorbed by the body.

Conclusion

While CBD and CBG may help alleviate some ADHD symptoms, they are not medications and do not replace proven medical treatments. If you decide to try them, do so cautiously and under professional guidance. Future research may provide more clarity on their real effectiveness in treating ADHD.

What is D9 THCV?

D9 THCV is a minor cannabinoid found mainly in naturally occurring cannabis strains from Africa, Asia, and the Middle East. Like other cannabinoids, it interacts with the human body's endocannabinoid system (ECS), which regulates various physiological processes such as mood, appetite, pain, and inflammation.

Unlike delta-9 THC, D9 THCV has a different chemical structure and mechanism of action, leading to unique interactions with ECS receptors, particularly CB1 and CB2 receptors.

How Does D9 THCV Work?

D9 THCV is often described as a "biphasic" compound due to its dual-action nature:

• At low dosesIn small amounts, D9 THCV acts as a CB1 receptor antagonist, potentially neutralizing the psychoactive effects of delta-9 THC. This makes it attractive to those seeking therapeutic benefits without experiencing a "high."
• At higher dosesIn larger amounts, D9 THCV can function as a CB1 receptor agonist, producing mild psychoactive effects, although significantly weaker than those of delta-9 THC.

Potential Benefits of D9 THCV

While research on D9 THCV is still in its early stages, preliminary studies and user experiences suggest several possible advantages:

1. Appetite Suppression
   Unlike delta-9 THC, which stimulates appetite ("the munchies"), D9 THCV may reduce appetite. This characteristic is being explored as a potential aid for weight management and metabolic health.
2. Increased Energy and Focus
   Many users report heightened energy levels, alertness, and mental clarity after consuming D9 THCV, often referring to it as the "sports car" of cannabinoids.
3. Blood Glucose Regulation
   Early studies suggest that D9 THCV may help regulate blood sugar levels and improve insulin sensitivity, offering potential benefits for managing diabetes, particularly type 2 diabetes.
4. Anti-Inflammatory Properties
   Like many other cannabinoids, D9 THCV may have anti-inflammatory effects, which could be beneficial for conditions such as arthritis or inflammatory bowel diseases.
5. Neuroprotective Effects
   Some studies indicate that D9 THCV may have neuroprotective properties, potentially aiding in the treatment of neurodegenerative diseases such as Parkinson’s or Alzheimer’s.

D9 THCV and EU Regulations

The legality of cannabinoids in the European Union depends primarily on their origin and THC content. The legal status of D9 THCV depends on whether it is derived from industrial hemp with a THC content below 0.3% or from medical cannabis. In the EU, all cannabinoid products must comply with relevant regulations, including general EU food safety laws if marketed as supplements.

Before purchasing or using D9 THCV products, it is crucial to check local regulations to ensure compliance with national laws.

How to Use D9 THCV?

D9 THCV is available in various forms, including oils, tinctures, supplements, and vape cartridges. The correct dosage depends on factors such as body weight, tolerance, and desired effects. New users are advised to start with a low dose and gradually increase it until the desired outcome is achieved.

Conclusion

D9 THCV is a fascinating cannabinoid with unique properties that have the potential to impact both the health and medical sectors. Its appetite-suppressing, energy-boosting, and metabolism-supporting effects make it a promising compound for future research and applications.

As with any new cannabinoid, consult a healthcare professional before use, especially if you have chronic conditions or take other medications.

What is Hempacco?

Hempacco is an innovative product that combines the natural gifts of hemp with the benefits of a smoke-free lifestyle. Its main ingredient is CBD or CBG hemp, extracted from hemp flowers and leaves, not tobacco. This means Hempacco contains no nicotine or harmful chemicals associated with traditional tobacco products.

Purity and Naturalness

One of the main reasons people choose Hempacco is its purity and naturalness. The hemp used in this product is often grown organically, adhering to natural principles. This means Hempacco is free from harmful pesticides and other contaminants.

Additionally, CBD and CBG hemp have several potential health benefits. They may help alleviate stress, anxiety, and pain, and support overall well-being. Therefore, by choosing Hempacco, you can enjoy the potential benefits of these hemp compounds without worrying about harmful effects.

Alternative to Tobacco

Hempacco is an ideal tobacco alternative for those looking to quit smoking tobacco. Its smoke is a tastier and healthier option, offering the enjoyment of smoking without the risks associated with nicotine addiction. It is also great for those who prefer smoking for relaxation or a pleasant taste experience.

How to Use Hempacco?

Hempacco is easy to use and available in various forms, including loose, so it can be mixed with other hemp or tobacco products, or pre-rolled variants to simplify the smoking experience further.

Conclusion

Hempacco is a healthy and pure alternative to tobacco, made from 100% CBD or CBG hemp flowers and leaves. Its purity, naturalness, and potential health benefits make it an attractive choice for those who want to enjoy smoking without the risks associated with tobacco. Additionally, Hempacco is environmentally friendly and sustainable, as it is based on natural hemp, which is safe for both your health and the environment.

If you are looking for a natural and healthy alternative to support a smoke-free lifestyle, consider trying Hempacco. It can be a step towards a healthier and cleaner future.

The European Parliament has no final say on the review of agricultural policy, but European cannabis activists praised the overwhelming voices for bringing the THC limits for European cannabis into line with those used in America.
"An increase in THC levels would allow new varieties to enter the market and be developed, resulting in better adaptation of crops to the climatic conditions of the different territories of the EU," the European Industrial Cannabis Association said in a statement on Monday.
The vote was taken to establish the European Parliament's position on the proposed reform of the common agricultural policy, which will determine how the European Union's agricultural subsidies will be implemented after 2020. Changes affecting the Cannabis Industry included:
* Amendments 8 and 93, which would increase the field of cannabis plants THC limit of the current 0.2% level to 0.3%.
* Amendment 234 to add cannabis to the sectors covered by EU marketing standards, allowing, where possible, criteria for the classification of products, their appearance, consistency, product characteristics and restrictions on the use of certain substances and practices to be established.
The power to adopt and amend legislation and decide on the EU budget is shared between the European Parliament, the Council of the European Union and the European Commission. Members of the European Parliament are directly elected by EU voters.

CBD cannabis sales It is legal in Estonia. CBDITALY e-store products such as CBD e-liquid, cannabis flowers and other products contain less than 0.2% THC.

Studies are still ongoing:
The Canadian study focuses on so-called cytokine storms, which are one of the symptoms of Covid-19 and cause inflammation, swelling, pain. Loss of organ function can lead to the death of cells in the body by the immune system. One of the researchers surveyed by Espresso said they used active ingredients extracted from home-grown cannabis plants to carry out laboratory tests. There are about 400 different varieties of cannabinoids and terpenoids with different levels. The results recorded the possible effects of the virus so that they had less chance of infecting us. In addition, some specific strains of cannabis would be good anti-inflammatory and cytokine storm inhibitors. In short, this is great news worth exploring. The fact that other scientists are using cannabis as an ally in the fight against the coronavirus 10 thousand kilometers away suggests that this is not so wrong. In fact, even in Israel, there is more than one study that suggests that CBD and the combination of terpenes may be truly effective in treating some of the effects of the virus on the human body, and in particular cytokine storms. Despite the prejudices of traditional suspects, research on this subject is still evolving, even in Italy.

Francesco Della Valle, president of Epitech Group, a biological pharmacology company founded in 2001 with offices in Saccolongo (Padua) and Pozzuoli, told Espresso how their adventure began: "The cell he is talking about is highly micronized and performs a wide variety of biological functions related to chronic and neuralgic pain, including inflammatory processes. It is also a substance produced by our body's endocannabinoid system, similar to the substance in cannabis. (endocannabinoids). In this case, it would be good to specify that this cell does not cure coronavirus, but it can be a significant helper that stimulates the immune system to prepare and protect itself.
has a future. on tulevikku.
Reading these complex studies, we feel that we need to continue to do research because there is potential for cannabis. Many of them are still unexplored. The virus found us unprepared, but now that we know it better and are waiting for the vaccine (free and universal), it would be right to use all the tools we have already tested to limit its power, such as CBD. Another thing that must not be underestimated is the need to give a privileged way to a safe endopharmaceutical based on a natural substance that we produce ourselves. What would be the best?

What is CBD?
CBD is one of over 100 compounds known as cannabinoids found in the cannabis plant. It is the second largest cannabinoid after tetrahydrocannabinol (THC), accounting for up to 40% of the plant extract. Unlike THC, CBD has no psychoactive effects, which means that it does not create a cloudy state in us. No matter how CBD affects your body, it works differently. It is believed to stimulate certain receptors that help reduce inflammation in the body and reduce pain and anxiety. Stops the breakdown of anandamide in the brain (a chemical often referred to as the "bliss molecule"). This allows the anandamide to stay in your body longer, helping to relieve pain and strengthen the brain. CBD also regulates the production of inflammatory molecules called cytokines, thereby reducing inflammation and pain. CBD can also help treat depression symptoms. Because human studies are currently limited, the full health effects of CBD remain unknown.

Can CBD help weight Loss? CBD's job is to improve various aspects of health, including weight loss. Here are some of the possible effects.

May speed up metabolism and reduce food intake..
Preliminary research suggests that CBD can lower food intake and boost metabolism, which can promote weight loss. For example, animal studies show that CBD affects body weight by interacting with the CB1 and CB2 receptors in lymphoid tissue and the brain. These receptors are thought to play an important role in metabolism and food intake. In a two-week study, rats were injected daily with CBD at doses of 2.5 and 5 mg per kg of body weight. Weight loss was achieved with both doses, but was significantly higher with the higher dose. It is important to note that CBD was administered by injection and not orally. In another rat study, CBD caused a significant reduction in food intake compared to other cannabinoids, including cannabigerol and cannabinol. While these results are promising, there are not enough human studies to support this and more research is needed.

May help darken fat.
There are two types of fat in your body - white and brown. White fat is the primary form responsible for storing and supplying energy, insulating, and lining your organs. It is also the type of fat most commonly associated with chronic diseases like diabetes and heart disease when it accumulates excessively. Brown fat is responsible for generating heat by burning calories. Normal weight people usually have more brown fat than overweight people. White fat can be turned brown by exercising, getting enough sleep, and tempering. Interestingly, research shows that CBD can help with this process. A test tube study found CBD promoted "darkening" of white fat. It enhances the expression of certain genes and proteins that make brown fat.
In any case, human studies are needed to confirm this effect.

Marijuana use is associated with lower body weight.
Although marijuana use is usually associated with increased food intake, those who use marijuana products weigh less than those who do not. For example, a survey of over 50,000 people found that those who used cannabis at least 3 days a week had an overweight rate of 14-17%. Compared to those who have not used marijuana in the past 12 months, this percentage is 22-25%. Since CBD is also found in marijuana, it has been linked to this. However, researchers believe that cannabinoids in general, including CBD, affect appetite, metabolism, and other body functions related to weight.

Can CBD Promote Weight Gain?
Хотя CBD может положительно влиять на аппетит и потерю веса, он также может вызывать увеличение веса. Некоторые исследования показали, что CBD увеличивает аппетит. Фактически, одним из наиболее распространенных побочных эффектов лечения CBD является изменение аппетита. В одном исследовании исследователи опросили родителей 117 лечившихся детей, которые использовали CBD для лечения эпилепсии. Хотя родители сообщили об уменьшении симптомов эпилепсии, 30% из них заявили, что масло CBD значительно повысило аппетит их детей. Исследования показывают, что CBD может влиять на аппетит по-разному. В одном трехмесячном исследовании участвовали 23 ребенка с синдромом Драве, типом эпилепсии, с дозой до 11,4 мг CBD на килограмм массы тела (25 мг / кг). У одних детей появился аппетит, у других - снизился. Кроме того, недавний обзор 2409 человек, употребляющих CBD, показал, что 6,35% из них испытали усиление чувства голода в качестве побочного эффекта. Необходимы дополнительные исследования, чтобы понять полное влияние CBD на аппетит, поскольку, похоже, оно варьируется. Многие факторы, такие как генетика и используемый продукт, могут повлиять на чувство голода при приеме CBD.

Should you try CBD oil to lose weight? Weight loss?

Although it's unclear, is CBD oil effective for weight loss, it has been shown to improve health in other good ways. It is relatively safe and has a low risk of side effects. More research is needed to determine, especially in humans, how this affects weight. The existing results are still relatively weak and inconsistent. Therefore, CBD oil is not recommended as an effective weight loss method. Better to try other weight loss tips instead - especially since CDB products can be expensive.

In conclusion..
CBD oil is an increasingly popular cannabis product, often touted as an effective weight loss aid. However, current research shows no clear effect on weight. While some research suggests CBD can boost metabolism by decreasing body fat and appetite, other studies show an increase in appetite. Until more research is completed, it is best to rely on other weight loss methods, such as diet and lifestyle changes.

Is CBD Legal?
Cannabis-derived CBD products (with less than 0.2% THC) are legal at the European level, but still illegal under some national laws, such as in Slovakia.

Inflammation and pain
A study published in the journal Bioorganic & Medicinal Chemistry shows that CBD-l has anti-inflammatory properties and it plays a role in the treatment of pain. This can be helpful after an intense workout. The pain that athletes feel when their muscles are exhausted is often the result of microscopic muscle rupture and inflammation. This microfracture is an important part of muscle growth because it allows the body to increase strength by increasing muscle.
CBD can help reduce this inflammation and better prepare your body for another workout. In addition, when a muscle is in pain, it may signal to the body that it is a necessary defense mechanism to limit muscle contraction to prevent muscle damage. While this response is natural and generally healthy, it may not be the best for athletic performance. By reducing the signals that pass through the body, CBD oil can deal with the body's reactions to muscle contractions, muscle tension and cramps.
Night sleep
Good sleep at night and plenty of rest are essential for an athlete's recovery and good results. Sleep allows the body to regenerate and restore damaged muscle fibers. CBD promotes moderate sleep patterns for better sleep quality and duration.
Mental health
Attention and concentration during sports is the main trick. Some athletes use pre-workout supplements, such as caffeine, to improve concentration. However, CBD can also help increase concentration by reducing stress or anxiety. CBD has been shown to have anti-anxiety properties that reduce the body's stress response. This is important because the body experiences intense muscle tension during exercise. It can be triggered by the stress hormone cortisol, which signals the body to reduce protein synthesis. Fortunately, a 2016 study found that CBD can increase the presence of chemicals such as serotonin (a happiness hormone) to help treat stress reactions in the body.

Is CBD a prohibited substance for athletes?
In addition to these great advantages, an important question arises for competitive athletes. Because the CBD helps improve performance, does it qualify as doping?
In January 2019, the World Anti-Doping Agency (WADA) published an updated list of Prohibited Substances. The report removed the CBD from this list and encourages other legislators to do the same. However, it is important to note that other cannabinoids such as THC and synthetic cannabinoids remain banned. If you are an athlete who competes at a high or professional level and who must pass a doping test at a competition, it is advisable to check the official rules of the competition. In sports environments where cannabinoids are allowed, this change has allowed many athletes to use CBD (for edema and inflammation) (instead of ibuprofen, for example) and may have fewer adverse side effects.
Do professional athletes use CBD? Until recently, the use of CBD in sports has been disgraced. But that has changed. Many athletes have publicly announced the use of CBD products and talked about their experiences and how to improve their performance. Below are the main athletes who use CBD:
Bubba Watson (PGA Tour golfer - still competing)
Terrell Davis (NFL - retired)
Ryan VandenBussche (NHL - retired)
Nate Diaz (MMA Fighter - still competing)
Gina Mazany (UFC fighter - still competing)
Final Thoughts on CBD for Athletes: CBD can help you achieve better physical or athletic performance. Previous evidence suggests that CBD can contribute to better and easier recovery after intense physical exertion by reducing inflammation, treating pain, promoting sleep, and reducing stress. Athletes who want to improve their workout recovery and improve their athletic performance should consider taking a CBD.

If you want to buy CBD products in Estonia, then CBD store Coffeeshop Tallinn (CBD ITALY STORE) on hea valik. Meil on suurim valik kvaliteetseid kanepitooteid Itaaliast.

These molecules lose their acid group and become decarboxylated becoming THC, CBD and CBC. Since CBG is "depleted" when converted to other states, plants with a high CBG content tend to have a low THCA or CBDA content and vice versa. CBGA is the parent molecule of many cannabinoids found in cannabis. Unlike its THC derivative, CBG is not psychoactive. It has shown interesting anti-inflammatory properties, as well as its ability to protect against neurons. Some studies have shown its ability to inhibit the growth of cancer cells; it is also an effective antibacterial, anti-spasmodic stimulant and stimulates appetite. Many of its benefits are similar to THCA and CBDAwhich makes sense as they are chemically similar. Before turning into THCA, CBDA, and CBCA, CBGA can take a different path through enzymatic changes and become CBGVA, which is the precursor to another type of cannabinoid: THCVA, CBDVA, and CBCVA. The letter V in this set of cannabinoids refers to cannabivarin classified as propyl cannabinoid; this group contains a propyl chain instead of a pentyl chain within the molecule. While this difference may suggest some variation in the effects of these cannabinoids, most of them act similarly to their pentyl cousins. The exception to this rule is THCV or tetrahydocannabivarin.
THCV: As a tetrahydrocannabivar As mentioned, THCV begins life as a CBGVA and is therefore modified by enzymes. It has a different ability than other cannabinoids to suppress appetite instead of stimulating it. No other known cannabinoid works in this way, and it is for this reason that THCV has attracted enormous interest in science. In addition to suppressing appetite, THCV has the ability to promote bone growth and healing.
CBC: Cannabichromene Another promising cannabinoid is CBC or Cannabichromene. Another common cannabinoid in CBC is a CBGA product such as THC and CBD. CBC appears to activate other secondary receptors, and for this reason it works well in topical preparations. Because of this, it can be used as a molecule in acne treatment, which significantly reduces excess sebum production in the skin. CBC has proven to be most effective for topical application. Combined with its antibacterial, anti-inflammatory and analgesic properties, it can be ideal for a wide variety of skin conditions. Finally, a complete blood count (CBC) stimulates spastic gastric motility without causing constipation, which is a secondary effect of many conventional medicines.
CBN: Kannabinool
Unlike other cannabinoids, which result from enzymatic changes within the plant, THC is converted to CBN after prolonged sun exposure in nature. It has traditionally been associated with “poor quality cannabis,” as high CBN levels tend to cause headaches and increase fatigue after smoking. However, we now know that a small amount of CBN is required to produce significant hypnotic effects, and 5 mg may be as effective as a 10 mg dose of diazepam, a common drug also used for sleep. As mentioned, all cannabinoids have a CBGA precursor. The plant then directs the CBGA to convert to other cannabinoids throughout its life cycle through synthesis, enzymes that chemically convert cannabinoids to other cannabinoids. This is determined by the needs of the plant and the amount of cannabinoid precursors available. We are still discovering the role that each of these cannabinoids plays in the plant, but we can safely assume that THCA, CBCA and CBDA benefit the plant to some extent because they appear in greater concentration in the plant. Most other cannabinoids, while potent and beneficial for medicinal purposes, don't seem to provide much to the plant. As a reminder, THC is actually present in very small amounts in the cannabis plant, as opposed to THCA, which is present in abundance (in relation to the species and genetic characteristics of cannabis). Only after additional research, selection, study of certain genetics and understanding of the cannabis plant and its natural mechanisms can we uncover the secrets of these unusual substances, "unusual cannabinoids".